Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.
BMJ. 2013 Dec 19;347:f6879. doi: 10.1136/bmj.f6879.
To investigate dietary fibre intake and any potential dose-response association with coronary heart disease and cardiovascular disease.
Systematic review of available literature and dose-response meta-analysis of cohort studies using random effects models.
The Cochrane Library, Medline, Medline in-process, Embase, CAB Abstracts, ISI Web of Science, BIOSIS, and hand searching.
Prospective studies reporting associations between fibre intake and coronary heart disease or cardiovascular disease, with a minimum follow-up of three years and published in English between 1 January 1990 and 6 August 2013.
22 cohort study publications met inclusion criteria and reported total dietary fibre intake, fibre subtypes, or fibre from food sources and primary events of cardiovascular disease or coronary heart disease. Total dietary fibre intake was inversely associated with risk of cardiovascular disease (risk ratio 0.91 per 7 g/day (95% confidence intervals 0.88 to 0.94)) and coronary heart disease (0.91 (0.87 to 0.94)). There was evidence of some heterogeneity between pooled studies for cardiovascular disease (I(2)=45% (0% to 74%)) and coronary heart disease (I(2)=33% (0% to 66%)). Insoluble fibre and fibre from cereal and vegetable sources were inversely associated with risk of coronary heart disease and cardiovascular disease. Fruit fibre intake was inversely associated with risk of cardiovascular disease.
Greater dietary fibre intake is associated with a lower risk of both cardiovascular disease and coronary heart disease. Findings are aligned with general recommendations to increase fibre intake. The differing strengths of association by fibre type or source highlight the need for a better understanding of the mode of action of fibre components.
调查膳食纤维摄入量与冠心病和心血管疾病的相关性及其潜在的剂量反应关系。
系统综述现有文献，并对采用随机效应模型的队列研究进行剂量-反应荟萃分析。
Cochrane 图书馆、Medline、Medline 正在处理、Embase、CAB 摘要、ISI Web of Science、BIOSIS 和手工检索。
报告膳食纤维摄入量与冠心病或心血管疾病之间相关性的前瞻性研究，随访时间至少 3 年，且发表于 1990 年 1 月 1 日至 2013 年 8 月 6 日期间的英文文献。
共有 22 项队列研究符合纳入标准，报告了总膳食纤维摄入量、膳食纤维亚型或膳食纤维的食物来源与心血管疾病或冠心病的主要事件。总膳食纤维摄入量与心血管疾病风险呈负相关（风险比为 7g/d 时的 0.91[95%置信区间 0.88 至 0.94]）和冠心病（0.91[0.87 至 0.94]）。对于心血管疾病（I²=45%[0%至 74%]）和冠心病（I²=33%[0%至 66%]），合并研究之间存在一定的异质性。不溶性纤维和来自谷物和蔬菜的纤维与冠心病和心血管疾病的风险呈负相关。水果纤维摄入量与心血管疾病风险呈负相关。
膳食纤维摄入量增加与冠心病和心血管疾病风险降低相关。这些发现与增加膳食纤维摄入量的一般建议一致。不同纤维类型或来源的关联强度不同，突出了需要更好地了解纤维成分的作用模式。
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