Süliová J, Macková N, Hvizdosová M, Gábor J
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(5):605-14.
The effect of cyclophosphamide on the organ weight, DNA and basic protein content in nuclei of bone marrow, thymus and spleen of rats was studied. Animals were examined 6, 12 and 24 hours and 3, 5, 10, 20 and 30 days after intraperitoneal application of cyclophosphamide in the doses of 100 and 200 mg X kg-1 of body weight. From the 5th day after application a marked decrease in weight and cellularity of all organs was observed. Amounts of DNA and basic proteins in nuclei of bone marrow and spleen were higher as compared with controls and their increase occurred prior to recovery of cellularity and organ weight, that was initiated within 5 and 10 days after cyclophosphamide treatment. Changes in the thymus persisted for a longer period of time and recovery was incomplete even at the day 30 after cyclophosphamide application. In accordance with these data no increase in DNA and basic protein amounts in the thymus nuclei was observed.
研究了环磷酰胺对大鼠骨髓、胸腺和脾脏器官重量、DNA及细胞核碱性蛋白含量的影响。以100和200mg·kg⁻¹体重的剂量腹腔注射环磷酰胺后，分别在6、12和24小时以及3、5、10、20和30天对动物进行检查。从用药后第5天开始，观察到所有器官的重量和细胞数量明显下降。与对照组相比，骨髓和脾脏细胞核中的DNA和碱性蛋白含量更高，且其增加发生在细胞数量和器官重量恢复之前，而细胞数量和器官重量的恢复在环磷酰胺治疗后5至10天内开始。胸腺的变化持续时间更长，即使在环磷酰胺用药后第30天，恢复也不完全。根据这些数据，未观察到胸腺细胞核中DNA和碱性蛋白含量增加。
