Markina E V, Maksimova G F, Ianovskiĭ O G, Koroleva N A, Zaĭtsevskaia E V
Eksp Klin Farmakol. 1992 Nov-Dec;55(6):38-40.
CBA mice were given a single Desferal dose (50 mg/kg). The mice received 3H-Thymidine 1 hour before they were killed. They were killed 1, 2, 6, or 9 hours after Desferal. Radiometry, and autoradiography were used to determine the level of DNA synthesis. Desferal was found to stimulate splenic 3H-incorporation 3 hours after drug injection and to increase the DNA-synthesizing cell fraction. In contrast, the agent inhibited 3H-incorporation in the bone marrow and thymus 9 hours after injection. This suppressive affect was accompanied by a decrease in the DNA-synthesizing cell fraction in these organs. In the thymus, there was a significant increase in the DNA-synthesizing cell fraction among lymphoblasts 1 and 3 hours following the administration of Desferal.
给CBA小鼠单次注射去铁胺剂量（50毫克/千克）。小鼠在处死前1小时接受3H-胸腺嘧啶核苷。在注射去铁胺后1、2、6或9小时将它们处死。使用放射测量法和放射自显影术来确定DNA合成水平。发现去铁胺在药物注射后3小时刺激脾脏3H掺入，并增加DNA合成细胞分数。相比之下，该药物在注射后9小时抑制骨髓和胸腺中的3H掺入。这种抑制作用伴随着这些器官中DNA合成细胞分数的降低。在胸腺中，给药后1和3小时，成淋巴细胞中DNA合成细胞分数显著增加。
