Sato T, Kishimoto A, Kumagai M, Yazaki K, Hata S
Hokkaido Igaku Zasshi. 1986 Nov;61(6):928-34.
A 40-year-old housewife was observed with chief complaints of syncope and palpitation. The electrocardiogram indicated premature ventricular ectopic complexes of the torsade de pointes. Serum potassium level was low because of thiazide-induced hypokalemia for the treatment of transient hypertension. Even after the disappearance of threatening ventricular arrhythmias and normalization of serum potassium level, prolongation of QT interval was continuously persisted. Thiazide induced hypokalemia might have some roles on producing ventricular ectopic activity in prolonged QT syndrome as shown in our case.
一名40岁的家庭主妇因晕厥和心悸为主诉前来就诊。心电图显示为尖端扭转型室性早搏。由于噻嗪类药物导致低钾血症用于治疗短暂性高血压,血清钾水平较低。即使威胁性室性心律失常消失且血清钾水平恢复正常后,QT间期仍持续延长。如我们病例所示,噻嗪类药物引起的低钾血症可能在长QT综合征中产生室性异位活动方面起到一定作用。