Leader M, Collins M, Patel J, Henry K
Histopathology. 1987 Jan;11(1):63-72. doi: 10.1111/j.1365-2559.1987.tb02609.x.
In this study we examined 198 sarcomas, 38 carcinomas, 13 'tumours with a spindle cell component' and 22 malignant melanomas with a commercial monoclonal vimentin antibody. All histopathological material was formalin fixed and paraffin embedded. The results show this antibody to be a sensitive and specific marker of mesenchymal derivation or differentiation. It is a useful tool in separating sarcomas from most carcinomas, and in separating malignant melanomas from carcinomas. When used in combination with a cytokeratin antibody it identifies carcinosarcomas and synovial sarcomas.
在本研究中，我们使用一种商用单克隆波形蛋白抗体检测了198例肉瘤、38例癌、13例“具有梭形细胞成分的肿瘤”以及22例恶性黑色素瘤。所有组织病理学材料均经福尔马林固定和石蜡包埋。结果显示，该抗体是间充质来源或分化的敏感且特异的标志物。它是区分肉瘤与大多数癌以及区分恶性黑色素瘤与癌的有用工具。当与细胞角蛋白抗体联合使用时，它可识别癌肉瘤和滑膜肉瘤。
