Diabetes Center of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
Institute for Laboratory and Transfusion Medicine of the Heart and Diabetes Center NRW, University Clinic of the Ruhr-University Bochum, Bad Oeynhausen, Germany.
Horm Metab Res. 2014 Jun;46(7):490-2. doi: 10.1055/s-0033-1363225. Epub 2013 Dec 19.
Recent evidence suggests that omega-3 polyunsaturated fatty acids [n-3 PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], improve insulin sensitivity in humans. In a double-blind, placebo-controlled, randomized, crossover study, we investigated the effects of EPA/DHA on paraoxonase-1 activity as well as fasting and postprandial levels of circulating adiponectin and leptin in 34 subjects with type 2 diabetes mellitus who received daily for 6 weeks either 2 g purified EPA/DHA or olive oil (placebo), separated by a 6 weeks washout. At the end of each treatment, measurements were performed in fasting state and 2, 4, and 6 h following a standardized high-fat meal (600 kcal). No significant differences in fasting and postprandial circulating adiponectin, leptin, and paraoxonase-1 activity were seen between n-3 PUFAs and placebo. Our data do not support an insulin sensitizing effect of n-3 PUFAs by means of influencing circulating adipocytokines in this population. Clinical Trial Register Number: NCT00328536.
最近的证据表明，ω-3 多不饱和脂肪酸（n-3 PUFA：二十碳五烯酸（EPA）和二十二碳六烯酸（DHA））可改善人类的胰岛素敏感性。在一项双盲、安慰剂对照、随机交叉研究中，我们研究了 EPA/DHA 对人血清对氧磷酶-1 活性以及 34 例 2 型糖尿病患者空腹和餐后循环脂联素和瘦素水平的影响，这些患者在 6 周的洗脱期后分别接受每日 2g 纯化的 EPA/DHA 或橄榄油（安慰剂）治疗 6 周。在每个治疗结束时，在空腹状态下以及在标准化高脂肪餐后 2、4 和 6 小时进行测量（600 千卡）。在 n-3 PUFA 和安慰剂之间，空腹和餐后循环脂联素、瘦素和对氧磷酶-1 活性没有显著差异。我们的数据不支持 n-3 PUFA 通过影响该人群的循环脂肪细胞因子来发挥胰岛素增敏作用。临床试验注册号：NCT00328536。
