Jacobo-Cejudo M Gorety, Valdés-Ramos Roxana, Guadarrama-López Ana L, Pardo-Morales Rosa-Virgen, Martínez-Carrillo Beatriz E, Harbige Laurence S
Faculty of Medicine, Universidad Autónoma del Estado de México, Paseo Tollocan esq. Jesús Carranza, Col. Moderna de la Cruz, Toluca 50180, Mexico.
Instlituto Materno-Infantil del Estado de México, Paseo Colón s/n, Col. Villa Hogar, Toluca 50170, Mexico.
Nutrients. 2017 Jun 3;9(6):573. doi: 10.3390/nu9060573.
Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with 3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of 3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults.
In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily. Baseline and 24-week anthropometric and biochemical measurements included glucose, insulin, glycosylated hemoglobin (Hb1Ac), leptin, adiponectin, resistin, and lipid profile; 3 PUFA intake was calculated in g/day.
Waist circumference and blood glucose showed significant reductions in the FOG group ( = 0.001 and = 0.011, respectively). Hb1Ac ( = 0.009 and = 0.004), leptin ( < 0.000 and < 0.000), and leptin/adiponectin ratio ( < 0.000 and < 0.000) decreased significantly in both groups after 24 weeks (FOG and PG respectively). Serum resistin (FOG p < 0.000 and PG p = 0.001), insulin (FOG < 0.000 and PG < 0.000), and HOMA-IR (FOG p = 0.000 and PG p < 0.000) increased significantly in both groups. FOG had an overall improvement in the lipid profile with a significant decrease in triacylgycerols ( = 0.002) and atherogenic index ( = 0.031); in contrast, the PG group had increased total cholesterol ( < 0.000), non-HDL cholesterol ( < 0.000), and atherogenic index ( = 0.017).
We found a beneficial effect of 3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.
2型糖尿病（T2DM）伴有慢性低度炎症，脂肪因子分泌失衡，胰岛素抵抗加重。补充3种多不饱和脂肪酸（PUFA）可降低T2DM患者的炎症标志物，本研究旨在探讨补充3种PUFA对墨西哥成年T2DM患者脂肪因子、代谢控制和血脂谱的影响。
在一项随机、单盲、安慰剂对照的前瞻性研究中，54例T2DM患者每天接受520mg富含二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）的鱼油（FOG）或安慰剂（PG）。基线及24周时的人体测量和生化指标包括血糖、胰岛素、糖化血红蛋白（Hb1Ac）、瘦素、脂联素、抵抗素和血脂谱；计算3种PUFA的每日摄入量（g）。
FOG组腰围和血糖显著降低（分别为P = 0.001和P = 0.011）。24周后，两组糖化血红蛋白（P = 0.009和P = 0.004）、瘦素（P < 0.000和P < 0.000）及瘦素/脂联素比值（P < 0.000和P < 0.000）均显著降低（分别为FOG组和PG组）。两组血清抵抗素（FOG组P < 0.000，PG组P = 0.001）、胰岛素（FOG组P < 0.000，PG组P < 0.000）及胰岛素抵抗指数（HOMA-IR）（FOG组P = 0.000，PG组P < 0.000）均显著升高。FOG组血脂谱总体改善，甘油三酯（P = 0.002）和致动脉粥样硬化指数（P = 0.031）显著降低；相比之下，PG组总胆固醇（P < 0.000）、非高密度脂蛋白胆固醇（P < 0.000）和致动脉粥样硬化指数（P = 0.017）升高。
我们发现补充3种PUFA对腰围、血糖、糖化血红蛋白、瘦素、瘦素/脂联素比值和血脂谱有有益影响，两组脂联素无显著变化，抵抗素、胰岛素和HOMA-IR升高。
