Khananashvili M M, Karsanov N V
Int J Psychophysiol. 1987 Jan;4(4):307-18. doi: 10.1016/0167-8760(87)90043-2.
In experimental informational neurosis, accompanied by the development of stable arterial hypertension, tachycardia and dystrophic alterations in myocardium, the contractile protein ability to generate force and produce work as well as the power of the contractile process are significantly decreased and so is the intensity of Ca2+ transport through membranes of sarcoplasmic reticulum and mitochondria. Ca2+ content in these structures and energetic supply to the cardiac muscle do not change as compared with the control. Noradrenaline content in myocardium increases 5-fold compared with the control and 2.5-fold compared with the norm, while blood content falls to zero (sympathetic neuro-muscular contact is 'locked up' for noradrenaline outflow into the blood); dopamine content increases. Adenylate cyclase sensitivity to the stimulating effect of noradrenaline and NaF diminishes. Basal activity of phosphodiesterase increases, and its sensitivity to the inhibitory action of high calcium concentrations decreases. The disturbance in these systems may, on the one hand, be due to neural effects, and pressure overload of the heart, on the other hand, to the sharp rise in noradrenaline content in the myocardium and the change in the activity of cyclic adenosine monophosphate enzymes. It is suggested that similar changes may take place in the human myocardium and may underlie the cardiac weakness.
在实验性信息神经症中，伴随着稳定的动脉高血压、心动过速以及心肌营养不良性改变的发展，心肌收缩蛋白产生力量和做功的能力以及收缩过程的功率显著降低，通过肌浆网和线粒体膜的Ca2+转运强度也降低。与对照组相比，这些结构中的Ca2+含量以及心肌的能量供应没有变化。心肌中的去甲肾上腺素含量与对照组相比增加了5倍，与正常水平相比增加了2.5倍，而血液中的含量降至零（交感神经 - 肌肉接触因去甲肾上腺素向血液中的流出而“锁定”）；多巴胺含量增加。腺苷酸环化酶对去甲肾上腺素和NaF刺激作用的敏感性降低。磷酸二酯酶的基础活性增加，其对高钙浓度抑制作用的敏感性降低。这些系统的紊乱一方面可能是由于神经效应和心脏压力过载，另一方面是由于心肌中去甲肾上腺素含量的急剧增加以及环磷酸腺苷酶活性的变化。有人认为，人类心肌中可能也会发生类似的变化，并且可能是心脏衰弱的基础。
