State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Planta Med. 2014 Feb;80(2-3):215-22. doi: 10.1055/s-0033-1360179. Epub 2013 Dec 19.
Seven new triterpenoid saponins, schekwangsiensides A-G (1-7), and a new triterpenoid, schekwangsienin (8), together with nine known triterpenoids and saponins (9-17), were isolated from the aerial parts of Schefflera kwangsiensis. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 4, 8, 9, and 15 (10 µM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
从广西鹅掌柴的地上部分分离得到了 7 个新的三萜皂苷，即 schekwangsiensides A-G（1-7）和一个新的三萜，即 schekwangsienin（8），以及 9 个已知的三萜和皂苷（9-17）。这些化合物的结构是基于光谱数据分析和化学证据确定的。此外，在体外实验中，化合物 4、8、9 和 15（10μM）对 D-半乳糖胺诱导的 HL-7702 细胞损伤表现出中等的肝保护活性。
