来自长柱金丝桃的保肝柴胡皂苷类似物。
Hepatoprotective saikosaponin homologs from Comastoma pedunculatum.
作者信息
Cui Bao-Song, Qiao Yong-Qi, Yuan Yi, Tang Li, Chen Hui, Li Yan, Li Shuai
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
College of Life and Environmental Science, Central University for Nationalities, Beijing, People's Republic of China.
出版信息
Planta Med. 2014 Nov;80(17):1647-56. doi: 10.1055/s-0034-1383123. Epub 2014 Sep 24.
Eight new triterpenoid saponins, the saikosaponin homologs comastomasaponins A-H (1-8), as well as a known triterpenoid (9) and eight known saponins (10-17) were isolated from the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated spectroscopically, and their hepatoprotective activity and cytotoxic activity were evaluated against five human tumor cell lines in vitro. Compounds 1, 5-12, 14, 15, and 17 exhibited potent hepatoprotective activity, and compound 11 displayed cytotoxic activity against HCT-8, Bel-7402, BGC-825, A549, and A2780 human tumor cell lines.
从长柱金丝桃的地上部分分离得到8个新的三萜皂苷，即柴胡皂苷同系物瘤毛獐牙菜皂苷A - H（1 - 8），以及1个已知的三萜类化合物（9）和8个已知的皂苷（10 - 17）。通过光谱学方法阐明了这些化合物的结构，并在体外对5种人肿瘤细胞系评估了它们的保肝活性和细胞毒性活性。化合物1、5 - 12、14、15和17表现出较强的保肝活性，化合物11对HCT - 8、Bel - 7402、BGC - 825、A549和A2780人肿瘤细胞系具有细胞毒性活性。
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