Puterman Eli, Epel Elissa S, O'Donovan Aoife, Prather Aric A, Aschbacher Kirstin, Dhabhar Firdaus S
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA,
Int J Behav Med. 2014 Dec;21(6):936-45. doi: 10.1007/s12529-013-9368-0.
Social connections moderate the effects of high negative affect on health. Affective states (anger, fear, and anxiety) predict interleukin-6 (IL-6) reactivity to acute stress; in turn, this reactivity predicts risk of cardiovascular disease progression.
Here, we examined whether perceived social support mitigates the relationship between negative affect and IL-6 stress reactivity.
Forty-eight postmenopausal women completed a standardized mental lab stressor with four blood draws at baseline and 30, 50, and 90 min after the onset of the stressor and anger, anxiety, and fear were assessed 10 min after task completion. Participants self-rated levels of social support within a week prior to the stressor.
Only anger was related to IL-6 stress reactivity-those experiencing high anger after the stressor had significant increases in IL-6. IL-6 reactivity was marginally associated with perceived support, but more strikingly, perceived support mitigated anger associations with IL-6 stress reactivity.
Supportive ties can dampen the relationship of anger to pro-inflammatory reactivity to acute stress. Implications to cardiovascular disease are discussed.
社会关系可调节高度负面情绪对健康的影响。情感状态（愤怒、恐惧和焦虑）可预测白细胞介素-6（IL-6）对急性应激的反应性；反过来，这种反应性可预测心血管疾病进展的风险。
在此，我们研究了感知到的社会支持是否会减轻负面情绪与IL-6应激反应性之间的关系。
48名绝经后女性完成了一项标准化的心理实验室应激源测试，在基线以及应激源开始后30、50和90分钟时进行了四次血液抽取，并在任务完成后10分钟评估了愤怒、焦虑和恐惧情况。参与者在应激源测试前一周内对社会支持水平进行了自我评估。
只有愤怒与IL-6应激反应性相关——应激源后经历高度愤怒的人IL-6显著增加。IL-6反应性与感知到的支持存在微弱关联，但更显著的是，感知到的支持减轻了愤怒与IL-6应激反应性之间的关联。
支持性的人际关系可以减弱愤怒与急性应激促炎反应性之间的关系。并讨论了其对心血管疾病的影响。
