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内皮素 B 受体表达与食管鳞癌的肿瘤血管生成和预后相关。

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma.

机构信息

Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

Division of Clinical and Investigative Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

出版信息

Br J Cancer. 2014 Feb 18;110(4):1027-33. doi: 10.1038/bjc.2013.784. Epub 2013 Dec 19.

DOI:10.1038/bjc.2013.784
PMID:24357795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3929870/
Abstract

BACKGROUND

The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC).

METHODS

We evaluated ETBR expression in 107 patients with OSCC by immunohistochemistry. Microvessel density (MVD) and lymphatic vessel density were assessed by CD31 and D2-40 immunostaining, respectively. Furthermore, CD4, CD8, and CD45RO+ tumour-infiltrating lymphocytes (TILs) were immunohistochemically analysed.

RESULTS

Sixty-one (57%) cases showed high expression of ETBR. Endothelin receptor type B expression was correlated with several clinicopathological factors including tumour differentiation, tumour depth, and lymph node metastasis. The overall and disease-specific survival rates were significantly lower in patients with high ETBR expression than patients with low expression. Furthermore, multivariate analysis revealed that ETBR status was an independent prognostic factor for patient survival. Mechanistic analysis indicated that MVD was significantly higher in tumour tissues with high ETBR expression compared with those with low expression, suggesting that angiogenesis may be a key mechanism in tumour progression and metastasis of OSCC mediated by ETBR expression. By contrast, there were no significant correlations between TILs and ETBR expression.

CONCLUSION

Endothelin receptor type B has a pivotal role in oesophageal cancer and may be therapeutic target for this intractable malignancy.

摘要

背景

内皮素轴在几种人类恶性肿瘤中具有关键作用。本研究旨在阐明内皮素受体 B（ETBR）在人食管鳞状细胞癌（OSCC）中的临床重要性。

方法

我们通过免疫组织化学评估了 107 例 OSCC 患者的 ETBR 表达。微血管密度（MVD）和淋巴管密度分别通过 CD31 和 D2-40 免疫染色评估。此外，还通过免疫组织化学分析了 CD4、CD8 和 CD45RO+肿瘤浸润淋巴细胞（TIL）。

结果

61 例（57%）病例表现出 ETBR 的高表达。ETBR 表达与包括肿瘤分化、肿瘤深度和淋巴结转移在内的几种临床病理因素相关。高 ETBR 表达患者的总生存率和疾病特异性生存率明显低于低表达患者。此外，多变量分析显示 ETBR 状态是患者生存的独立预后因素。机制分析表明，高 ETBR 表达的肿瘤组织中的 MVD 明显高于低表达的肿瘤组织，提示血管生成可能是 ETBR 表达介导的 OSCC 肿瘤进展和转移的关键机制。相比之下，TILs 与 ETBR 表达之间没有显著相关性。

结论

内皮素受体 B 在食管癌中具有关键作用，可能是这种难治性恶性肿瘤的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/a55356cc2723/bjc2013784f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/94a2ba534f63/bjc2013784f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/89af526a1594/bjc2013784f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/cc64e5d90c57/bjc2013784f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/40e9f96440e5/bjc2013784f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/a55356cc2723/bjc2013784f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/94a2ba534f63/bjc2013784f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/89af526a1594/bjc2013784f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/cc64e5d90c57/bjc2013784f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/40e9f96440e5/bjc2013784f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/3929870/a55356cc2723/bjc2013784f5.jpg

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3
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