Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.
Hum Pathol. 2014 Apr;45(4):858-65. doi: 10.1016/j.humpath.2013.08.030. Epub 2014 Jan 8.
Astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in tumorigenesis and progression. The aim of this study was to explore AEG-1 expression in oral squamous cell carcinoma (OSCC) and to assess whether it is associated with microvessel density (MVD), metastasis, and survival. Specimens from 87 patients with OSCC were investigated by immunohistochemistry staining for AEG-1 and MVD. By statistical analysis, we studied the correlations between the expression of AEG-1 and MVD and various clinicopathological factors, including overall survival (OS). We found that AEG-1 was highly expressed in 51.72% of OSCC. Expression was closely correlated with differentiation, clinical stage, T classification, and lymph node metastasis. The MVD had similar results. Expression of AEG-1 correlated positively with MVD. The lymph node metastatic rate in patients with high AEG-1/high MVD was significantly higher than in patients with high AEG-1/low MVD, low AEG-1/high MVD, or low AEG-1/low MVD. Patients with high AEG-1 expression showed far lower OS rates than those with low expression. For MVD, there were similar results. Only AEG-1 and MVD expression were independent prognostic factors for OS by multivariate analysis. Expression of AEG-1 may be correlated with tumor angiogenesis and metastasis and is a valuable prognostic factor in patients with OSCC.
星形胶质细胞上调基因 1（AEG-1）的表达在各种人类癌症中上调，并在肿瘤发生和进展中发挥重要作用。本研究旨在探讨 AEG-1 在口腔鳞状细胞癌（OSCC）中的表达情况，并评估其是否与微血管密度（MVD）、转移和生存相关。通过免疫组织化学染色检测 87 例 OSCC 患者标本中的 AEG-1 和 MVD。通过统计学分析，我们研究了 AEG-1 和 MVD 的表达与各种临床病理因素（包括总生存（OS））之间的相关性。我们发现 AEG-1 在 51.72%的 OSCC 中高表达。表达与分化、临床分期、T 分类和淋巴结转移密切相关。MVD 也有类似的结果。AEG-1 的表达与 MVD 呈正相关。高 AEG-1/高 MVD 患者的淋巴结转移率明显高于高 AEG-1/低 MVD、低 AEG-1/高 MVD 或低 AEG-1/低 MVD 患者。AEG-1 高表达的患者 OS 率明显低于低表达的患者。对于 MVD，也有类似的结果。只有 AEG-1 和 MVD 表达是 OS 的独立预后因素。AEG-1 的表达可能与肿瘤血管生成和转移有关，是 OSCC 患者有价值的预后因素。
