Crispe I N, Bevan M J
J Immunol. 1987 Apr 1;138(7):2013-8.
Subpopulations of thymocytes have been characterized phenotypically and functionally in relation to their expression of the marker defined by the monoclonal antibody J11d. Cortical-type L3T4+, Lyt-2+ thymocytes are all J11d+. Thymocytes that share the phenotype L3T4-, Lyt-2+ with peripheral Lyt-2+ T cells contain a J11d+ and a J11d- subset. These J11d- cells behave like peripheral Lyt-2+ T cells in two functional assays: they form clonal growth bursts in response to immobilized antibody against the T cell antigen receptor, and they act as precursors of alloreactive cytotoxic T cells. The J11d+ cells are inert in both of these assays. In contrast, L3T4+, Lyt-2- thymocytes do not contain a J11d+ subset.
已根据胸腺细胞对单克隆抗体J11d所定义标志物的表达情况，在表型和功能上对其亚群进行了表征。皮质型L3T4 +、Lyt-2 +胸腺细胞均为J11d +。与外周Lyt-2 + T细胞具有相同L3T4 -、Lyt-2 +表型的胸腺细胞包含一个J11d +亚群和一个J11d -亚群。在两项功能试验中，这些J11d -细胞的行为类似于外周Lyt-2 + T细胞：它们在针对T细胞抗原受体的固定抗体刺激下形成克隆生长爆发，并且它们作为同种反应性细胞毒性T细胞的前体。在这两项试验中，J11d +细胞均无活性。相比之下，L3T4 +、Lyt-2 -胸腺细胞不包含J11d +亚群。
