桂利嗪对小鼠和大鼠IgE抗体介导的过敏反应的影响。

Effect of cinnarizine on IgE antibody mediated allergic reaction in mice and rats.

作者信息

Nagai H, Yakuo I, Yamada H, Inagaki N, Goto S, Koda A

出版信息

J Pharmacobiodyn. 1986 Nov;9(11):923-7. doi: 10.1248/bpb1978.9.923.

DOI:10.1248/bpb1978.9.923

Abstract

The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187, histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD4-induced reaction. Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells.

摘要

研究了桂利嗪对小鼠和大鼠免疫球蛋白E（IgE）抗体介导的过敏反应的影响。硝苯地平和曲尼司特用作对照药物。口服和腹腔注射桂利嗪均能明显抑制IgE抗体介导的小鼠耳部被动皮肤过敏反应（PCA）引起的染料渗漏。桂利嗪对PCA的抑制作用与硝苯地平相当，且优于曲尼司特。桂利嗪能明显抑制组胺和钙离子载体A 23187（A 23187）引起的小鼠耳部毛细血管通透性增加，但对白三烯D4（LTD4）引起的增加无抑制作用。硝苯地平能抑制A 23187、组胺和LTD4引起的毛细血管通透性增加。曲尼司特能抑制A 23187诱导的血管炎，但对组胺或LTD4诱导的反应无抑制作用。桂利嗪对大鼠腹腔肥大细胞抗原或A 23187引起的组胺释放无明显影响。硝苯地平和曲尼司特能抑制大鼠腹腔肥大细胞抗原和A 23187引起的组胺释放。