Tanizaki Y, Akagi K, Lee K N, Townley R G
Int Arch Allergy Appl Immunol. 1983;72(2):102-9. doi: 10.1159/000234850.
The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 micrograms/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine release than cromolyn sodium. In mast cells, nonimmunologically stimulated by concanavalin A, compound 48/80, and calcium ionophore A23187, nifedipine exerted considerable inhibitory effects on both 45Ca and histamine release.
使用大鼠皮肤和腹膜肥大细胞，在过敏反应和非特异性反应中检测了钙通道拮抗剂之一硝苯地平的作用。硝苯地平（100微克/大鼠）和色甘酸钠（5毫克/大鼠）均可抑制由IgE抗体介导的大鼠被动皮肤过敏反应。组胺或乙酰甲胆碱诱导的皮肤反应未被抑制，而血清素诱导的皮肤反应则被这些药物轻微抑制。硝苯地平可抑制卵清蛋白刺激的致敏肥大细胞中45Ca的摄取和组胺释放。在主动致敏细胞中，硝苯地平似乎对抑制45Ca摄取更有效，但对组胺释放的抑制作用比色甘酸钠弱。在由伴刀豆球蛋白A、化合物48/80和钙离子载体A23187进行非免疫刺激的肥大细胞中，硝苯地平对45Ca摄取和组胺释放均有相当大的抑制作用。
