Ferrell W R, Russell N J
J Physiol. 1986 Oct;379:407-16. doi: 10.1113/jphysiol.1986.sp016260.
Electrical stimulation of the cut distal end of the posterior articular nerve (p.a.n.) of the cat knee joint resulted in significant extravasation of plasma proteins and erythrocytes into the synovial cavity of the knee. This effect was mediated by group IV afferents (C fibres) since stimulation of p.a.n. suprathreshold for group II or III afferents but subthreshold for group IV afferents did not produce extravasation. Unmyelinated sympathetic efferent fibres in the joint nerve did not contribute to the extravasation and were responsible for a diminution of this response as shown by the enhanced extravasation occurring after adrenergic blockade. Plasma and erythrocyte extravasation was mediated by afferents containing substance P (SP), as demonstrated by the reversible abolition of extravasation when the substance P antagonist (D-Pro4,D-Trp7,9,10)-SP (4-11) was injected into the synovial cavity. In some animals it was observed that electrical stimulation of the cut distal end of p.a.n. in one limb resulted in extravasation in the contralateral knee joint. It is suggested that articular C fibre afferents could make a significant neurogenic contribution to the initiation or maintenance of inflammatory joint disease.
对猫膝关节后关节神经（p.a.n.）切断的远端进行电刺激，会导致血浆蛋白和红细胞大量渗入膝关节的滑膜腔。这种效应是由IV类传入纤维（C纤维）介导的，因为对II类或III类传入纤维为阈上刺激而对IV类传入纤维为阈下刺激的p.a.n.刺激不会产生渗出。关节神经中无髓鞘的交感传出纤维对渗出没有作用，并且如肾上腺素能阻断后渗出增强所示，它们会导致这种反应减弱。血浆和红细胞渗出是由含P物质（SP）的传入纤维介导的，当将P物质拮抗剂（D-Pro4，D-Trp7,9,10）-SP（4-11）注入滑膜腔时，渗出的可逆性消除证明了这一点。在一些动物中观察到，对一侧肢体的p.a.n.切断远端进行电刺激会导致对侧膝关节渗出。有人提出，关节C纤维传入可能对炎症性关节疾病的起始或维持有重大的神经源性作用。
