Ohashi Toru, Nishino Hirohito, Nishimoto Yositane, Arai Yoko, Koizuka Izumi
Department of otorhinolaryngology, Hadano Red Cross Hospital.
Acta Otolaryngol. 2014 Mar;134(3):275-9. doi: 10.3109/00016489.2013.860655. Epub 2013 Dec 23.
An abnormally slower action potential (AP) recovery from adaptation (decreased recovery, dR) was characteristically detected in many ears with sensorineural hearing loss (SNHL) but not Meniere's disease and idiopathic sudden SNHL. We assumed that this abnormal AP recovery from adaptation was attributed to an imbalance in the distributions of auditory neurons with high and low spontaneous firing rates. The significant difference of initial hearing level between dR and normal AP recovery groups (nR) was assumed to partially result from AP recovery being determined by the inner hair cell synapse, and not from outer hair cells.
This study aimed to detect the AP recovery pattern in SNHL.
Electrocochleography (ECochG) was performed transtympanically in 30 patients with SNHL. AP recovery was measured by a paired click stimulation paradigm as a function of inter-click intervals from 5 to 100 ms.
The high prevalence of dR (9 of 30 ears) appears to be a characteristic ECochG finding in SNHL. Initial hearing level differed significantly between dR and nR groups.
在许多感音神经性听力损失（SNHL）患者的耳朵中，可特征性地检测到动作电位（AP）从适应性恢复异常缓慢（恢复减少，dR），但梅尼埃病和特发性突发性感音神经性听力损失患者则未出现这种情况。我们推测，这种AP从适应性恢复异常是由于高自发放电率和低自发放电率的听觉神经元分布失衡所致。dR组和正常AP恢复组（nR）之间初始听力水平的显著差异，部分原因被认为是AP恢复由内毛细胞突触决定，而非外毛细胞。
本研究旨在检测感音神经性听力损失患者的AP恢复模式。
对30例感音神经性听力损失患者经鼓膜进行电耳蜗图（ECochG）检查。通过配对短声刺激范式，测量AP恢复情况，作为5至100毫秒点击间隔的函数。
dR的高发生率（30只耳朵中有9只）似乎是感音神经性听力损失患者电耳蜗图的一个特征性表现。dR组和nR组之间的初始听力水平存在显著差异。
