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北欧的社会经济地位与皮肤恶性黑色素瘤。

Socioeconomic status and cutaneous malignant melanoma in Northern Europe.

机构信息

Dermatological Research Department D92, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400, Copenhagen, Denmark.

出版信息

Br J Dermatol. 2014 Apr;170(4):787-93. doi: 10.1111/bjd.12800.

Abstract

Socioeconomic status (SES) is associated with cutaneous malignant melanoma (CMM) in Northern Europe, despite equal access to health care. SES per se is not responsible for this association, which must be ascribed to important risk factors for CMM such as intermittent ultraviolet radiation (UVR) exposure, and screening for CMM possibly owing to a greater knowledge and understanding of CMM. Our review of the literature showed that high SES is associated with increased risk of CMM, thinner tumours, increased survival and decreased mortality from CMM - the latter shown among women, and in recent studies also among men. There is evidence that high SES is associated with sun holidays, whereas low SES is associated with the use of sunbeds. Findings suggest that high SES is associated with the use of physicians and dermatologists for marks and moles, possibly owing to more knowledge and better understanding of CMM. We conclude that there has been a true increase in CMM incidence among high SES individuals in Northern Europe probably due to past intense intermittent UVR exposure, especially in connection with sun holidays. However, the increased risk of CMM and a better outcome of CMM in high SES individuals may also be conditioned by frequent recourse to physicians, which may be ascribed to more knowledge and better understanding of CMM, although more studies on this subject are warranted. Thicker CMM tumours and increased CMM mortality among low SES individuals in recent decades may reflect exposure to intermittent UVR, such as the use of sunbeds, as well as delayed diagnosis.

摘要

社会经济地位(SES)与北欧的皮肤恶性黑色素瘤(CMM)有关,尽管有平等的医疗保健机会。SES 本身并不是导致这种关联的原因,这种关联必须归因于 CMM 的重要危险因素,如间歇性紫外线辐射(UVR)暴露,以及 CMM 的筛查,可能是由于对 CMM 的更多了解和理解。我们对文献的回顾表明,高 SES 与 CMM 的风险增加、肿瘤变薄、生存率提高和 CMM 死亡率降低有关——这在女性中有所体现,在最近的研究中也在男性中有所体现。有证据表明,高 SES 与阳光假期有关,而低 SES 与使用日光浴床有关。研究结果表明,高 SES 与医生和皮肤科医生治疗痣和痣有关,这可能是由于对 CMM 的更多了解和更好的理解。我们得出的结论是,北欧高 SES 人群中 CMM 的发病率确实有所增加,可能是由于过去间歇性 UVR 暴露强烈,尤其是与阳光假期有关。然而,高 SES 人群中 CMM 的风险增加和 CMM 的预后更好也可能是由于频繁寻求医生的治疗,这可能归因于对 CMM 的更多了解和更好的理解,尽管需要更多的研究来证实这一点。最近几十年来,低 SES 人群中 CMM 肿瘤较厚和 CMM 死亡率增加可能反映了间歇性 UVR 的暴露,如使用日光浴床,以及诊断延迟。

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