School of Chemical Engineering, The University of Adelaide, Engineering North Building, SA 5005, Australia.
Nanomedicine (Lond). 2014;9(8):1263-75. doi: 10.2217/nnm.13.93. Epub 2013 Dec 20.
This study aimed to demonstrate radiofrequency (RF)-triggered release of drugs and drug carriers from drug-eluting implants using gold nanoparticles as energy transducers.
MATERIALS & METHODS: Titanium wire with a titania nanotube layer was used as an implant loaded with indomethacin and micelles (tocopheryl PEG succinate) as a drug and drug carrier model. RF signals were generated from a customized RF generator to trigger in vitro release.
RESULTS & DISCUSSION: Within 2.5 h, 18 mg (92%) of loaded drug and 14 mg (68%) of loaded drug carriers were released using short RF exposure (5 min), compared with 5 mg (31%) of drug and 2 mg (11%) of drug carriers without a RF trigger. Gold nanoparticles can effectively function as RF energy transducers inside titania nanotubes for rapid release of therapeutics at arbitrary times.
The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required.
本研究旨在展示使用金纳米粒子作为能量转换器，通过射频（RF）触发从载药植入物中释放药物和药物载体。
钛丝表面涂有二氧化钛纳米管层，作为载有吲哚美辛和胶束（生育酚聚乙二醇琥珀酸酯）的植入物，作为药物和药物载体模型。使用定制的射频发生器产生 RF 信号以触发体外释放。
在 2.5 小时内，通过短 RF 暴露（5 分钟）释放了 18 毫克（92%）的负载药物和 14 毫克（68%）的负载药物载体，而没有 RF 触发的情况下仅释放了 5 毫克（31%）的药物和 2 毫克（11%）的药物载体。金纳米粒子可以在二氧化钛纳米管内部有效地作为 RF 能量转换器，实现任意时间的治疗药物快速释放。
本研究结果表明，RF 是一种有前途的策略，可用于需要按需输送治疗药物的植入式药物输送系统中的触发释放。
