Department of Chemical and Paper Engineering, Miami University, Oxford, Ohio 45056, USA.
J Pharm Sci. 2013 Jul;102(7):2341-8. doi: 10.1002/jps.23580. Epub 2013 May 8.
Developing coatings on implant surface as drug carriers can reduce organ toxicity and effectively deliver drug locally to the target compared with the oral approach. Titanium dioxide (TiO2) nanotube has great potential for this application for widely used Ti implants because of its high surface area, ability to promote bone growth, and biocompatibility. However, there are two issues needed to be solved before further advancing TiO2 nanotubes technology as drug carriers: uncontrolled drug release and poor mechanical properties. In this study, a drug carrier using a composite of biodegradable polymer/TiO2 nanotubes is engineered. Ibuprofen is selected as a concept drug because it is a commonly used anti-inflammatory, fever, and pain-reducing drug. In addition, ibuprofen has a very short plasma half-life of only 1-3 h. A simple characterization method is developed to investigate the infiltration of polymer into TiO2 nanotubes. Good infiltration was observed of polymer into TiO2 nanotubes. The synthesized drug carrier demonstrated much better sustained drug release profiles for ibuprofen of 5 days (low-molecular-weight polymer) and 9 days (high-molecular-weight polymer) compared with 30 min of pure TiO2 nanotubes. The drug carrier also exhibited much improved mechanical strength and flexibility compared with pure TiO2 nanotubes.
在植入物表面开发涂层作为药物载体可以减少器官毒性，并与口服途径相比，将药物有效地局部递送到靶标。由于具有高表面积、促进骨生长和生物相容性，二氧化钛（TiO2）纳米管在 Ti 植入物的广泛应用中具有很大的潜力。然而，在进一步推进 TiO2 纳米管技术作为药物载体之前，需要解决两个问题：药物释放不受控制和机械性能差。在本研究中，设计了一种使用可生物降解聚合物/TiO2 纳米管复合材料的药物载体。选择布洛芬作为概念药物，因为它是一种常用的抗炎、退热和止痛药物。此外，布洛芬的血浆半衰期非常短，只有 1-3 小时。开发了一种简单的表征方法来研究聚合物对 TiO2 纳米管的渗透。观察到聚合物很好地渗透到 TiO2 纳米管中。与纯 TiO2 纳米管相比，合成的药物载体表现出布洛芬的持续释放长达 5 天（低分子量聚合物）和 9 天（高分子量聚合物）的效果更好，而纯 TiO2 纳米管仅为 30 分钟。与纯 TiO2 纳米管相比，药物载体还表现出更好的机械强度和柔韧性。
