Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomiokahigashi, Kanazawa-ku, Yokohama, Kanagawa 236-0051, Japan.
J Cardiovasc Magn Reson. 2013 Dec 20;15(1):106. doi: 10.1186/1532-429X-15-106.
Long-term intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA) is associated with a low risk for cardiovascular disease. Phase-contrast cine cardiovascular magnetic resonance (PC cine CMR) can assess coronary flow reserve (CFR). The present study investigates the relationship between CFR evaluated by PC cine CMR and the serum EPA.
We studied 127 patients (male, 116 (91%); mean age, 72.2 ± 7.4 years) with known or suspected coronary artery disease (CAD). X-ray coronary angiography revealed no significant coronary arterial stenoses (defined as luminal diameter reduction ≥ 50% on quantitative coronary angiogram (QCA) analysis) in all study participants. Breath-hold PC cine CMR images of the coronary sinus (CS) were acquired to assess blood flow of the CS both at rest and during adenosine triphosphate (ATP) infusion. We calculated CFR as CS blood flow during ATP infusion divided by that at rest. Patients were allocated to groups according to whether they had high (n = 64, EPA ≥ 75.8 μg/mL) or low (n = 63, EPA < 75.8 μg/mL) median serum EPA.
CFR was significantly lower in the low, than in the high EPA group (2.54 ± 1.00 vs. 2.91 ± 0.98, p = 0.038). Serum EPA positively correlated with CFR (R = 0.35, p < 0.001). We defined preserved CFR as > 2.5, which is the previously reported lower limit of normal flow reserve without obstructive CAD. Multivariate analysis revealed that EPA is an independent predictor of CFR > 2.5 (odds ratio, 1.01; 95% confidence interval, 1.00 - 1.02, p = 0.008).
The serum EPA is significantly correlated with CFR in CAD patients without significant coronary artery stenosis.
长期摄入长链 n-3 多不饱和脂肪酸（n-3PUFAs），尤其是二十碳五烯酸（EPA），与心血管疾病风险降低相关。相位对比电影心血管磁共振（PC cine CMR）可评估冠状动脉血流储备（CFR）。本研究旨在探讨 PC cine CMR 评估的 CFR 与血清 EPA 之间的关系。
我们研究了 127 名（男，116 名（91%）；平均年龄，72.2±7.4 岁）患有已知或疑似冠状动脉疾病（CAD）的患者。所有研究参与者的 X 射线冠状动脉造影均未显示明显的冠状动脉狭窄（定量冠状动脉造影（QCA）分析显示管腔直径减少≥50%）。采集冠状动脉窦（CS）的屏气 PC cine CMR 图像，以评估 CS 在休息和三磷酸腺苷（ATP）输注期间的血流。我们将 ATP 输注期间 CS 血流除以休息时的血流，计算出 CFR。根据血清 EPA 的中位数将患者分为两组，高 EPA 组（n=64，EPA≥75.8μg/mL）和低 EPA 组（n=63，EPA<75.8μg/mL）。
低 EPA 组的 CFR 明显低于高 EPA 组（2.54±1.00 比 2.91±0.98，p=0.038）。血清 EPA 与 CFR 呈正相关（R=0.35，p<0.001）。我们将 CFR>2.5 定义为正常血流储备的先前报道的下限，无阻塞性 CAD。多变量分析显示 EPA 是 CFR>2.5 的独立预测因子（优势比，1.01；95%置信区间，1.00-1.02，p=0.008）。
在无明显冠状动脉狭窄的 CAD 患者中，血清 EPA 与 CFR 显著相关。
Zotero 插件
