青春期功能性下丘脑性闭经和神经性厌食症患者的心率变异性。
Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa.
机构信息
Clinic of Child and Adolescent Mental Health, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy.
Clinic of Child and Adolescent Mental Health, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy.
出版信息
Psychiatry Res. 2014 Feb 28;215(2):406-9. doi: 10.1016/j.psychres.2013.11.012. Epub 2013 Nov 20.
Aim of this study consisted in assessing the 24-h heart rate variability (HRV), a measure of autonomic nervous system (ANS) imbalance, in 21 adolescents with functional hypothalamic amenorrhea (FHA, 11 normogonadotropic, N-FHA, and 10 hypogonadotropic, Hy-FHA) compared to 21 patients with anorexia nervosa (AN) and 21 controls. As expected, subjects with AN showed a significant dysregulation in multiple HRV parameters, while Hy-FHA patients presented with a dysregulation in a few domains (SDNN, HFr), which was not present in girls with N-FHA, who showed values largely similar to controls. FHA might represent part of the AN biological spectrum, and a link between these two conditions might exist, possibly related to the degree of psychological and/or hormonal dysfunction.
本研究旨在评估 21 例功能性下丘脑性闭经（FHA，11 例正常促性腺激素，N-FHA 和 10 例低促性腺激素，Hy-FHA）青少年的 24 小时心率变异性（HRV），以评估自主神经系统（ANS）失衡，与 21 例神经性厌食症（AN）患者和 21 例对照者进行比较。正如预期的那样，AN 患者的多项 HRV 参数显示出明显的失调，而 Hy-FHA 患者仅在少数领域（SDNN，HFr）表现出失调，而 N-FHA 患者则没有，他们的数值与对照组非常相似。FHA 可能代表 AN 生物学谱的一部分，并且这两种情况之间可能存在联系，可能与心理和/或激素功能障碍的程度有关。
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