心率变异性作为神经性厌食症自主神经系统功能的一种测量指标。
Heart rate variability as a measure of autonomic nervous system function in anorexia nervosa.
作者信息
Petretta M, Bonaduce D, Scalfi L, de Filippo E, Marciano F, Migaux M L, Themistoclakis S, Ianniciello A, Contaldo F
机构信息
Institute of Internal Medicine, Cardiology, and Heart Surgery, University of Naples, Federico II, Italy.
出版信息
Clin Cardiol. 1997 Mar;20(3):219-24. doi: 10.1002/clc.4960200307.
BACKGROUND AND HYPOTHESIS
Alteration in sympathovagal balance may be a mechanism of increased cardiovascular mortality and sudden death of patients with anorexia nervosa. This study was undertaken to characterize cardiac autonomic control in patients with anorexia nervosa by means of heart rate variability analysis.
METHODS
Heart period variability by 24-h Holter recording was evaluated in 13 young women with anorexia nervosa, 10 constitutionally thin women, and 10 women of normal weight.
RESULTS
High-frequency power, a measure of parasympathetic modulation of heart rate, and all-time domain measures of heart rate variability were higher in patients with anorexia nervosa than in thin women and in those of normal weight. Thin women showed lower values of total power and of most components of power spectrum.
CONCLUSIONS
Our data demonstrate an increased vagal tone in young women with anorexia nervosa. The marked increase in parasympathetic activity, not in response to an increase in sympathetic activity, could be detrimental and may contribute to the higher cardiovascular mortality of these patients.
背景与假设
交感神经 - 迷走神经平衡的改变可能是神经性厌食症患者心血管死亡率增加和猝死的机制之一。本研究旨在通过心率变异性分析来描述神经性厌食症患者的心脏自主神经控制情况。
方法
对13名神经性厌食症年轻女性、10名体质消瘦女性和10名体重正常女性进行24小时动态心电图监测，评估心动周期变异性。
结果
神经性厌食症患者的高频功率（心率副交感神经调节的指标）以及心率变异性的所有时域测量值均高于消瘦女性和体重正常女性。消瘦女性的总功率和功率谱的大多数成分值较低。
结论
我们的数据表明神经性厌食症年轻女性的迷走神经张力增加。副交感神经活动的显著增加并非对交感神经活动增加的反应，可能是有害的，并且可能导致这些患者较高的心血管死亡率。
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