神经性厌食症患者自主心脏控制的改变。
Alterations of autonomic cardiac control in anorexia nervosa.
作者信息
Rechlin T, Weis M, Ott C, Bleichner F, Joraschky P
机构信息
Department of Psychosomatics and Psychiatry, University of Erlangen-Nuremberg, Germany.
出版信息
Biol Psychiatry. 1998 Mar 1;43(5):358-63. doi: 10.1016/s0006-3223(97)00026-7.
BACKGROUND
The authors investigated autonomic cardiac function in anorexia nervosa.
METHODS
Forty-eight patients, who in the present or past met the DSM-III-R criteria for anorexia nervosa, and 16 normal control subjects participated in a standardized analysis of heart rate variability during supine and standing postures.
RESULTS
Several heart rate variability parameters showed an inverse correlation to the present weight of the anorexic subjects. The values of the spectral power analyses were significantly (p < .01) lower in patients (n = 18) weighing less than 75% of ideal weight when compared to the results found in the control group; however, the heart rate variability parameters of anorexic subjects with restored weight (n = 12) did not differ from those of the control subjects.
CONCLUSIONS
The obtained results provide evidence for autonomic cardiac dysfunction in acutely ill anorexic patients. Further research is required to elucidate possible clinical consequences of these findings.
背景
作者研究了神经性厌食症患者的自主心脏功能。
方法
48名目前或过去符合神经性厌食症DSM-III-R标准的患者以及16名正常对照者参与了仰卧位和站立位心率变异性的标准化分析。
结果
几个心率变异性参数与厌食症患者的当前体重呈负相关。体重低于理想体重75%的患者（n = 18）的频谱功率分析值与对照组相比显著更低（p <.01）；然而，体重恢复的厌食症患者（n = 12）的心率变异性参数与对照者并无差异。
结论
所得结果为急性病厌食症患者的自主心脏功能障碍提供了证据。需要进一步研究以阐明这些发现可能的临床后果。
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