Vik-Mo H, Halvorsen F J, Thorsen E, Walde N H, Rosland G A
J Cardiovasc Pharmacol. 1987 Feb;9(2):129-34. doi: 10.1097/00005344-198702000-00001.
The effects of salbutamol, a relative specific beta 2-agonist, on hemodynamics and arterial blood oxygenation, were studied in 12 patients with chronic cor pulmonale. The studies were done during heart catheterization at rest (n = 12) and during arm bicycle exercise (n = 7) before and during salbutamol infusion of 0.2 microgram/kg/min. At rest, salbutamol significantly increased cardiac index on average by 31%, stroke volume index by 11%, and heart rate by 12 beats/min. Mean pulmonary artery pressure was not changed by salbutamol, whereas a small reduction in mean arterial pressure was observed. The vascular resistance was reduced by 15% in pulmonary and 24% in systemic circulation. Similar hemodynamic changes by salbutamol were observed during exercise. Arterial oxygen tension and saturation were not changed by salbutamol, but a significant rise in mixed venous oxygen saturation and oxygen delivery were observed both at rest and during exercise. Thus, salbutamol infusion improves the cardiac performance in patients with chronic cor pulmonale through a chronotropic effect combined with vasodilation in both the systemic and pulmonary circulation and thereby increased stroke volume. No deleterious effects on arterial blood oxygenation by salbutamol infusion were observed.
在12例慢性肺心病患者中研究了相对特异性β2-激动剂沙丁胺醇对血流动力学和动脉血氧合的影响。研究在心脏导管插入术期间进行，分别于静息状态（n = 12）和手臂自行车运动期间（n = 7），在输注沙丁胺醇0.2微克/千克/分钟之前和期间进行。静息时，沙丁胺醇使心脏指数平均显著增加31%，每搏量指数增加11%，心率增加12次/分钟。沙丁胺醇未改变平均肺动脉压，而平均动脉压有小幅降低。肺循环血管阻力降低15%，体循环血管阻力降低24%。运动期间观察到沙丁胺醇引起类似的血流动力学变化。沙丁胺醇未改变动脉血氧张力和饱和度，但静息和运动期间混合静脉血氧饱和度和氧输送均显著升高。因此，输注沙丁胺醇通过变时作用联合体循环和肺循环血管舒张改善慢性肺心病患者的心功能，从而增加每搏量。未观察到输注沙丁胺醇对动脉血氧合有有害影响。
