Komabayashi T, Izawa T, Suda K, Tsuboi M
Res Commun Chem Pathol Pharmacol. 1987 Jan;55(1):141-4.
The effects of monensin on the Na+,K+-ATPase activity and the release of amylase and sialic acid were investigated in dog submandibular gland pieces. Monensin stimulated the Na+,K+-ATPase activity and amylase release in a dose-dependent manner. Moreover, this agent increased the Na+,K+-ATPase activity and the release of amylase and sialic acid induced by pilocarpine. These results suggest that monensin increases the release of amylase and sialic acid in dog submandibular glands, in part, through the Na+ pump activated due to the Na+ influx.
在犬下颌下腺组织块中研究了莫能菌素对钠钾ATP酶活性以及淀粉酶和唾液酸释放的影响。莫能菌素以剂量依赖的方式刺激钠钾ATP酶活性和淀粉酶释放。此外，该药物增强了毛果芸香碱诱导的钠钾ATP酶活性以及淀粉酶和唾液酸的释放。这些结果表明，莫能菌素部分通过因钠离子内流而激活的钠泵增加犬下颌下腺中淀粉酶和唾液酸的释放。
