Frei A, Cottier C, Wunderlich P, Lüdin E
Stroke. 1987 Mar-Apr;18(2):373-9. doi: 10.1161/01.str.18.2.373.
The results of clinical trials investigating various therapies in acute ischemic stroke have been inconsistent. The effect of glycerol therapy and a combination therapy of glycerol and dextran was evaluated in a double-blind, placebo-controlled study. Repeated neurologic examinations (Day 0, Weeks 1, 6, 12, and 24) according to a modified Mathew score were performed on 62 patients. Statistical analysis showed no superiority of either treatment compared with placebo in acute ischemic stroke. A retrospective estimation of the Type II error of the study yielded approximately p = 0.25. A major side effect was hemolysis in 98% of patients treated with glycerol.
研究急性缺血性中风各种治疗方法的临床试验结果并不一致。在一项双盲、安慰剂对照研究中评估了甘油疗法以及甘油与右旋糖酐联合疗法的效果。根据改良的马修评分法，对62例患者进行了多次神经学检查（第0天、第1、6、12和24周）。统计分析表明，在急性缺血性中风中，两种治疗方法与安慰剂相比均无优势。对该研究的II型错误进行回顾性估计得出p约为0.25。一个主要副作用是接受甘油治疗的患者中有98%出现溶血。
