Hülser P J, Bernhart H, Marbach C, Kornhuber H H
Department of Neurology, University Hospital, Ulm, Federal Republic of Germany.
Eur Arch Psychiatry Neurol Sci. 1988;237(5):253-7. doi: 10.1007/BF00450543.
In an open pilot study 55 patients suffering from acute stroke were treated with Flunarizine, a calcium overload blocker, in addition to standard therapy including diet, physiotherapy, adequate management of accompanying disorders, and hemodilution. The initial high-dose i.v. treatment (2 X 25 mg Flunarizine/day) and the subsequent oral regimen were well-tolerated. The main side effect was slight transient weariness. No adverse effects regarding blood pressure, heart rate, enzymes, blood analysis, renal function and, especially, no extrapyramidal motor symptoms or depression were detected. Flunarizine may be regarded as a relatively safe drug in acute stroke. The probable beneficial effect on the patient's recovery will be evaluated in a multicenter double-blind study.
在一项开放性试验研究中，55例急性中风患者除接受包括饮食、物理治疗、妥善处理伴发疾病及血液稀释在内的标准治疗外，还使用了钙超载阻滞剂氟桂利嗪进行治疗。最初的大剂量静脉治疗（每日2次，每次25mg氟桂利嗪）及随后的口服方案耐受性良好。主要副作用为轻微短暂的疲倦。未检测到对血压、心率、酶、血液分析、肾功能有不良影响，尤其未发现锥体外系运动症状或抑郁。氟桂利嗪在急性中风中可被视为一种相对安全的药物。其对患者康复可能的有益作用将在一项多中心双盲研究中进行评估。
