Schneider F J
Z Gesamte Inn Med. 1986 Nov 15;41(22):613-8.
Interferons are endogenous proteins produced by vertebrates in response to viral infections and is immunoregulatory agents. Three types of interferon are known today: IFN-alpha, IFN-beta und IFN-gamma which show different degree of relationship to each other in molecular structure and activity. Several interferons are produced in large amount by recombinant DNA technology. Their most important properties are their antiviral activity, their antiproliferative and immunoregulatory activities. Clinical trials showed that interferons can be used as therapeutic agents in viral infections and malignant diseases. Results of treatment in certain viral infections or virally induced tumors and some particular haematologic malignancies are very good. Many frequent forms of tumors still respond less or not at all to interferon treatment. Interferons have many different effects in vivo and can act synergistically with other agents. Further success in cancer therapy can therefore be expected from investigations on optimum dose schedule and effective combination regimes.
干扰素是脊椎动物在病毒感染时产生的内源性蛋白质，是免疫调节剂。如今已知有三种类型的干扰素：α-干扰素、β-干扰素和γ-干扰素，它们在分子结构和活性上彼此呈现出不同程度的关联。几种干扰素通过重组DNA技术大量生产。它们最重要的特性是抗病毒活性、抗增殖活性和免疫调节活性。临床试验表明，干扰素可作为病毒感染和恶性疾病的治疗药物。在某些病毒感染、病毒诱导的肿瘤以及一些特定的血液系统恶性肿瘤中的治疗效果非常好。许多常见的肿瘤形式对干扰素治疗的反应仍然较小或根本没有反应。干扰素在体内有许多不同的作用，并且可以与其他药物协同发挥作用。因此，通过对最佳剂量方案和有效联合治疗方案的研究，有望在癌症治疗方面取得进一步的成功。
