Kaudewitz P, Burg G, Majiewski G, Gerdes J, Schwarting R, Braun-Falco O
Acta Derm Venereol. 1987;67(1):24-9.
The nature of the epidermal cellular infiltrate in pagetoid reticulosis is still subject to intense controversies. Using a panel of recently developed monoclonal antibodies against cell activation and proliferation associated antigens it was possible to demonstrate the activated state of numerous T cells within the lesional epidermis. Moreover approximately 10% of these T cells reacted with proliferation associated antigens. In addition macrophages and Langerhans' cells were found to represent a regular constituent of the epidermal infiltrate with a density clearly exceeding that of unaffected adjacent epidermis. The close apposition of activated T cells and monocytic cells suggests an intensive interaction of both cell types in the development of the pagetoid reticulosis lesion.
派杰样网状细胞增生症中表皮细胞浸润的性质仍存在激烈争议。使用一组针对细胞活化和增殖相关抗原的最新开发的单克隆抗体，有可能证明病变表皮内众多T细胞的活化状态。此外，这些T细胞中约10%与增殖相关抗原发生反应。另外，发现巨噬细胞和朗格汉斯细胞是表皮浸润的正常组成部分，其密度明显超过未受影响的相邻表皮。活化的T细胞和单核细胞的紧密并置表明这两种细胞类型在派杰样网状细胞增生症病变发展中存在强烈相互作用。
