Instituto de Productos Naturales y Agrobiología , Consejo Superior de Investigaciones Científicas (CSIC), Avda. Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
Org Lett. 2014 Jan 17;16(2):552-5. doi: 10.1021/ol403428p. Epub 2013 Dec 23.
An expedient methodology to synthesize macrocyclic compounds in one step based on the Nicholas reaction is disclosed. The key step features two intermolecular reactions followed by an intramolecular reaction from the starting dicobalt hexacarbonyl-propargylic complex. The macrocycles obtained were modified through [2 + 2 + 2] cycloaddition, generating two new C3-symmetric hexasubstituted benzene structures suitable for molecular recognition purposes.
本文公开了一种基于尼可拉斯反应一步法合成大环化合物的简易方法。关键步骤包括两步分子间反应，随后由起始二羰基六钴炔丙基配合物进行分子内反应。所得大环化合物通过[2+2+2]环加成进行修饰，生成了两种新的 C3 对称六取代苯结构，适用于分子识别目的。
