Dąbrowski Mariusz, Mielnik-Niedzielska Grażyna, Nowakowski Andrzej
Medical Faculty, Institute of Nursing and Health Sciences, University of Rzeszow, Poland.
Department of Pediatrics Otolaryngology Phoniatrics and Audiology, Medical University, Lublin, Poland.
Ann Agric Environ Med. 2013;20(4):773-8.
Hearing impairment in diabetic subjects is more prevalent than in the general population. Ageing, noise exposure and smoking are known as risk factors of hearing loss. The aim of this study was to assess whether other factors, such as HbA(1c), blood pressure, serum lipids and BMI have an impact on hearing function among relatively young diabetic subjects.
58 patients, 31 with type 1 diabetes and 27 with type 2 diabetes, aged < 45 years, with diabetes duration < 10 years and without overt hearing impairment were included. In all subjects, vital signs, laboratory tests, pure-tone audiometry and trancient-evoked otoacoustic emissions (TEOAE) were evaluated.
Hearing impairment was revealed in 20 subjects. This group had a lower HDL-cholesterol level compared with normal hearing patients (44.2 mg/dl vs. 57.6 mg/dl, p=0.007). Absence of otoacoustic emissions was diagnosed in 16 subjects. These patients also had a lower HDL-cholesterol level compared with subjects with TEOAE present (45.4 mg/dl vs. 55.2 mg/dl, p=0.018). Hearing threshold was inversely correlated with HDL-cholesterol level, and positively correlated with triglycerides. Patients with HDL-cholesterol level ≥50 mg/dl had lower hearing threshold at frequencies 0.5-12 kHz, as well as higher TEOAE amplitude. Subjects with triglycerides above median had a higher hearing threshold at frequencies 0.5-12 kHz, as well as lower TEOAE amplitude. Patients with elevated BMI (≥25 kg/m(2)) had a higher hearing threshold at frequencies 2-12 kHz, as well as lower TEOAE amplitude.
Hearing impairment is frequent among relatively young diabetic subjects. The preseted study reveals that factors like HDL-cholesterol, triglycerides, and BMI may affect hearing function in this group.
糖尿病患者的听力障碍比普通人群更为普遍。衰老、噪声暴露和吸烟是已知的听力损失风险因素。本研究的目的是评估其他因素，如糖化血红蛋白（HbA₁c）、血压、血脂和体重指数（BMI）是否对相对年轻的糖尿病患者的听力功能有影响。
纳入58例患者，其中1型糖尿病患者31例，2型糖尿病患者27例，年龄<45岁，糖尿病病程<10年且无明显听力障碍。对所有受试者进行生命体征、实验室检查、纯音听力测定和瞬态诱发耳声发射（TEOAE）评估。
20名受试者存在听力障碍。与听力正常的患者相比，该组高密度脂蛋白胆固醇（HDL - 胆固醇）水平较低（44.2mg/dl对57.6mg/dl，p = 0.007）。16名受试者被诊断为无耳声发射。与存在TEOAE的受试者相比，这些患者的HDL - 胆固醇水平也较低（45.4mg/dl对55.2mg/dl，p = 0.018）。听力阈值与HDL - 胆固醇水平呈负相关，与甘油三酯呈正相关。HDL - 胆固醇水平≥50mg/dl的患者在0.5 - 12kHz频率的听力阈值较低，TEOAE振幅较高。甘油三酯高于中位数的受试者在0.5 - 12kHz频率的听力阈值较高，TEOAE振幅较低。体重指数（BMI）升高（≥25kg/m²）的患者在2 - 12kHz频率的听力阈值较高，TEOAE振幅较低。
相对年轻的糖尿病患者中听力障碍很常见。本研究表明，HDL - 胆固醇、甘油三酯和BMI等因素可能影响该组患者的听力功能。
