Morikawa Y, Rosen M R, Meiri H, Robinson R B
Am J Physiol. 1987 Apr;252(4 Pt 2):H771-6. doi: 10.1152/ajpheart.1987.252.4.H771.
We used standard microelectrode techniques to study the effects of SC-72-14, a monoclonal antibody to eel electroplax, and tetrodotoxin (TTX) on the electrophysiological properties of neonatal and adult canine Purkinje fibers. SC-72-14, 7 ng/ml, depressed maximum upstroke potential (Vmax) and membrane responsiveness of adult but not neonatal fibers. In contrast, we previously had shown TTX to have a greater effect on neonatal than adult fibers (29). Even in the presence of SC-72-14, TTX continued to have a greater effect on the neonatal fibers. The effects of TTX and SC-72-14 were cumulative over the concentration range studied, and our results are consistent with their acting at different sites.
我们使用标准微电极技术研究了SC - 72 - 14（一种针对鳗鱼电板的单克隆抗体）和河豚毒素（TTX）对新生和成年犬浦肯野纤维电生理特性的影响。7纳克/毫升的SC - 72 - 14降低了成年纤维的最大上升电位（Vmax）和膜反应性，但对新生纤维没有影响。相比之下，我们之前已经表明TTX对新生纤维的影响比对成年纤维的影响更大（参考文献29）。即使在存在SC - 72 - 14的情况下，TTX对新生纤维的影响仍然更大。在研究的浓度范围内，TTX和SC - 72 - 14的作用是累积的，我们的结果与它们作用于不同位点一致。
