神经肌肉阻滞剂引起的皮肤组胺释放比较

Comparative cutaneous histamine release by neuromuscular blocking agents.

作者信息

Galletly D C

出版信息

Anaesth Intensive Care. 1986 Nov;14(4):365-9. doi: 10.1177/0310057X8601400407.

Abstract

Normal values of cutaneous wheal diameter following intradermal injection of six neuromuscular blocking drugs were determined. The relative cutaneous histamine-releasing ability of each drug was derived from calculated dose-response relationships. Equipotent neuromuscular blocking doses were found to have a cutaneous histamine releasing ability relative to pancuronium (= 1) of vecuronium 1.1: suxamethonium 1.7; alcuronium 5; atracurium 52; d-tubocurarine 172. A significant (P less than 0.001) variation was found between the dose-response slopes perhaps suggesting a variation in the mechanism of histamine release.

摘要

测定了皮内注射六种神经肌肉阻滞药物后皮肤风团直径的正常值。每种药物的相对皮肤组胺释放能力由计算出的剂量-反应关系得出。发现等效神经肌肉阻滞剂量相对于泮库溴铵（=1）的皮肤组胺释放能力为：维库溴铵1.1；琥珀胆碱1.7；阿库氯铵5；阿曲库铵52；d-筒箭毒碱172。在剂量-反应斜率之间发现了显著差异（P<0.001），这可能表明组胺释放机制存在差异。