Ertama P M
Ann Clin Res. 1982 Feb;14(1):15-26.
The effects of five commonly used neuromuscular blocking drugs on histamine liberation were studied in 105 surgical patients. After standard premedication with pethidine and atropine the patients were anaesthetized with thiopental sodium. d-Tubocurarine and succinylcholine caused significant histamine liberation while alcuronium, gallamine, and pancuronium did not appear to exert this effect. d-Tubocurarine seems to liberate histamine by acting directly on the blood cells thus causing a decrease of histamine in the whole blood and an elevation in plasma. On the other hand, the succinylcholine-induced liberation of histamine may be mediated by muscular fasciculations as it causes an elevation of histamine in whole blood and in plasma. No correlation was found between histamine liberation and blood pressure changes. Erythematous skin reactions were the only clinical sign of histamine liberation caused by intravenous administration of the neuromuscular blocking drugs.
在105例外科手术患者中研究了五种常用神经肌肉阻滞药物对组胺释放的影响。患者在接受哌替啶和阿托品标准术前用药后，用硫喷妥钠麻醉。d -筒箭毒碱和琥珀酰胆碱可引起显著的组胺释放，而阿库氯铵、加拉明和泮库溴铵似乎没有这种作用。d -筒箭毒碱似乎通过直接作用于血细胞来释放组胺，从而导致全血中组胺减少和血浆中组胺升高。另一方面，琥珀酰胆碱诱导的组胺释放可能由肌肉束颤介导，因为它会导致全血和血浆中组胺升高。未发现组胺释放与血压变化之间存在相关性。静脉注射神经肌肉阻滞药物引起的组胺释放的唯一临床体征是皮肤红斑反应。
