Org-NC 45引起的皮内组胺释放效应。与泮库溴铵、美库氯铵和d-筒箭毒碱的比较。

Intradermal histamine releasing effect caused by Org-NC 45. A comparison with pancuronium, metocurine and d-tubocurarine.

作者信息

Booij L H, Krieg N, Crul J F

出版信息

Acta Anaesthesiol Scand. 1980 Oct;24(5):393-4. doi: 10.1111/j.1399-6576.1980.tb01568.x.

DOI:10.1111/j.1399-6576.1980.tb01568.x

Abstract

Histamine release caused by Org-NC 45, pancuronium, metocurine and d-tubocurarine was determined by measuring the diameter of the redness and skin induration following the intradermal injection of these drugs. d-Tubocurarine and metocurine caused the largest diameter of redness and induration, followed by pancuronium. Org-NC 45 caused the smallest reaction. We conclude that Org-NC 45 may be the drug of choice in patients with asthma and allergic reactions.

摘要

通过测量皮内注射奥季-NC 45、泮库溴铵、美库氯铵和d-筒箭毒碱后红斑直径和皮肤硬结情况，来确定这些药物引起的组胺释放。d-筒箭毒碱和美库氯铵引起的红斑直径和硬结最大，其次是泮库溴铵。奥季-NC 45引起的反应最小。我们得出结论，奥季-NC 45可能是哮喘和过敏反应患者的首选药物。