Roarty Kevin, Rosen Jeffrey M
Breast Cancer Res. 2013 Dec 23;15(6):322. doi: 10.1186/bcr3592.
The mammary gland requires the coordinated efforts of multiple epithelial cell lineages to build an organized bilayered ductal network. How epigenetic regulators direct decisions of cell-fate and lineage determination in cooperation with intrinsic transcriptional factors and extrinsic signaling factors remains a fundamental question in the field of developmental biology. Recent work sheds new light on the role of the histone methylation reader Pygopus 2 in coordinating the balance of self-renewal Wnt signals with luminal-specific Notch signals in mammary epithelial lineage determination.
乳腺需要多种上皮细胞谱系的协同作用来构建一个有组织的双层导管网络。表观遗传调节因子如何与内在转录因子和外在信号因子合作指导细胞命运决定和谱系确定，仍然是发育生物学领域的一个基本问题。最近的研究为组蛋白甲基化阅读器Pygopus 2在乳腺上皮谱系确定中协调自我更新Wnt信号与管腔特异性Notch信号平衡的作用提供了新的线索。
