Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Department of Neuroscience, Baylor College of Medicine, Houston, TX.
Semin Pediatr Neurol. 2013 Dec;20(4):236-41. doi: 10.1016/j.spen.2013.10.004. Epub 2013 Oct 16.
The central nervous system is comprised of numerous cell types that work in concert to facilitate proper function and homeostasis. Disruption of these carefully orchestrated networks results in neuronal dysfunction, manifesting itself in a variety of neurologic disorders. Although neuronal dysregulation is causative of symptoms that manifest in the clinic, the etiology of these disorders is often more complex than simply a loss of neurons or intrinsic dysregulation of their function. In the adult brain, astrocytes comprise the most abundant cell type and play key roles in central nervous system physiology; therefore, it stands to reason that dysregulation of normal astrocyte function contributes to the etiology and progression of varied neurologic disorders. We review here some neurologic disorders associated with an astrocyte factor and discuss how the related astrocyte dysfunction contributes to the etiology or progression of these disorders or both.
中枢神经系统由多种细胞类型组成，这些细胞协同工作以促进正常功能和体内平衡。这些精心协调的网络的破坏会导致神经元功能障碍，表现为各种神经疾病。尽管神经元失调是导致临床症状的原因，但这些疾病的病因往往比神经元丢失或其功能的内在失调更为复杂。在成人大脑中，星形胶质细胞是最丰富的细胞类型，在中枢神经系统生理学中发挥关键作用；因此，星形胶质细胞正常功能的失调会导致各种神经疾病的病因和进展是合理的。在这里，我们回顾了一些与星形胶质细胞因子相关的神经疾病，并讨论了相关的星形胶质细胞功能障碍如何导致这些疾病的病因或进展，或两者兼而有之。
