Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6.
J Inorg Biochem. 2011 Nov;105(11):1513-7. doi: 10.1016/j.jinorgbio.2011.07.001. Epub 2011 Jul 23.
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
铝（Al）已被牵涉到多种神经疾病中。然而，使铝能够参与这些疾病的分子机制尚未完全阐明。我们使用星形胶质细胞作为大脑细胞系统的模型，揭示了受铝毒性影响的生化网络。在这篇综述中，我们揭示了铝对 ATP 产生和线粒体功能的抑制作用如何帮助产生产生脂肪的球状星形胶质细胞。这些生物学事件可能是铝引发脑疾病的原因之一。
