Yang Deng-Ho, Tu Chuan-Chou, Wang Shou-Cheng, Wei Cheng-Chung, Cheng Ya-Wen
Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., Taichung, 40201, Taiwan.
Rheumatol Int. 2014 Jul;34(7):971-7. doi: 10.1007/s00296-013-2926-6. Epub 2013 Dec 24.
Anti-cyclic citrullinated peptide (anti-CCP) antibody is highly specific for diagnosing rheumatoid arthritis (RA). Cigarette smoking is a lifestyle and environmental factor associated with anti-CCP production and is strongly associated with chronic obstructive pulmonary disease (COPD). This study assessed levels of anti-CCP antibodies and rheumatoid factor (RF) among patients with RA and COPD. The study sample comprised 63 patients with RA and 70 patients with COPD, all of whom underwent assessment of anti-CCP antibody and RF levels. Testing revealed that 54.2% of RA patients and 0% of COPD patients were positive for anti-CCP antibodies. Additionally, 82.5% of RA patients and 42% of COPD patients were positive for RF. Among RA patients, levels of anti-CCP antibodies were higher among smokers than among nonsmokers (242.7 ± 128.3 vs. 68.1 ± 112.1, P < 0.001). COPD patients had low titers of RF but were negative for anti-CCP antibodies. The presence of anti-CCP antibodies was a reliable serologic marker in RA diagnosis and was associated with cigarette smoking.
抗环瓜氨酸肽（anti-CCP）抗体对类风湿关节炎（RA）的诊断具有高度特异性。吸烟是一种与抗CCP产生相关的生活方式和环境因素，且与慢性阻塞性肺疾病（COPD）密切相关。本研究评估了RA和COPD患者中抗CCP抗体及类风湿因子（RF）的水平。研究样本包括63例RA患者和70例COPD患者，所有患者均接受了抗CCP抗体和RF水平的评估。检测显示，54.2%的RA患者抗CCP抗体呈阳性，而COPD患者中这一比例为0%。此外，82.5%的RA患者RF呈阳性，42%的COPD患者RF呈阳性。在RA患者中，吸烟者的抗CCP抗体水平高于不吸烟者（242.7±128.3 vs. 68.1±112.1，P<0.001）。COPD患者的RF滴度较低，但抗CCP抗体呈阴性。抗CCP抗体的存在是RA诊断中一种可靠的血清学标志物，且与吸烟有关。
