Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Phys Chem Chem Phys. 2014 Feb 14;16(6):2224-39. doi: 10.1039/c3cp53560f.
Surface enhanced Raman spectroscopy (SERS) is a powerful spectroscopic technique capable of detecting trace amounts of chemicals and identifying them based on their unique vibrational characteristics. While there are many complex methods for fabricating SERS substrates, there has been a recent shift towards the development of simple, low cost fabrication methods that can be performed in most labs or even in the field. The potential of SERS for widespread use will likely be realized only with development of cheaper, simpler methods. In this Perspective article we briefly review several of the more popular methods for SERS substrate fabrication, discuss the characteristics of simple SERS substrates, and examine several methods for producing simple SERS substrates. We highlight potential applications and future directions for simple SERS substrates, focusing on highly SERS active three-dimensional nanostructures fabricated by inkjet and screen printing and galvanic displacement for portable SERS analysis - an area that we believe has exciting potential for future research and commercialization.
表面增强拉曼光谱（SERS）是一种强大的光谱技术，能够检测痕量化学物质，并根据其独特的振动特性对其进行识别。虽然有许多用于制造 SERS 基底的复杂方法，但最近已经转向开发简单、低成本的制造方法，这些方法可以在大多数实验室甚至现场进行。只有开发出更便宜、更简单的方法，SERS 的广泛应用才有可能实现。在这篇观点文章中，我们简要回顾了几种更流行的 SERS 基底制造方法，讨论了简单 SERS 基底的特点，并研究了几种制造简单 SERS 基底的方法。我们强调了简单 SERS 基底的潜在应用和未来方向，重点关注通过喷墨和丝网印刷以及电化置换制造的具有高 SERS 活性的三维纳米结构，用于便携式 SERS 分析——我们认为这一领域具有令人兴奋的未来研究和商业化潜力。
