Bodger M P, Mounsey G L, Nelson J, Fitzgerald P H
Blood. 1987 May;69(5):1414-8.
Bsp-1 is an IgM murine monoclonal antibody raised against the human erythroblastic leukemia cell line (HEL) that reacts with basophils but not neutrophils or eosinophils. Western blotting techniques showed that Bsp-1 reacts with a 45-kilodalton surface antigen on HEL cells. The distribution of Bsp-1 antigen on leukemic cells is confined to a basophilic leukemia cell line, KU812, chronic myeloid leukemia with basophilia, and some cases of acute undifferentiated leukemia. Bsp-1 might therefore be a useful reagent for the study of basophil function and differentiation.
Bsp-1是一种针对人成红细胞白血病细胞系（HEL）产生的IgM鼠单克隆抗体，它与嗜碱性粒细胞反应，但不与中性粒细胞或嗜酸性粒细胞反应。蛋白质印迹技术表明，Bsp-1与HEL细胞上一种45千道尔顿的表面抗原发生反应。Bsp-1抗原在白血病细胞上的分布局限于嗜碱性白血病细胞系KU812、伴有嗜碱性粒细胞增多的慢性髓性白血病以及一些急性未分化白血病病例。因此，Bsp-1可能是研究嗜碱性粒细胞功能和分化的有用试剂。
