Department of Pediatrics, Division of Cardiology, Dr. Behçet Uz Children's Hospital, Alsancak, 35220, Izmir, Turkey.
Pediatrics. 2014 Jan;133(1):e138-42. doi: 10.1542/peds.2012-3427. Epub 2013 Dec 23.
Vitamin B12 is involved in the production of adrenaline from noradrenaline. It is the cofactor involved in catecholamine degradation and plays a role in myelin synthesis. The current study aimed to investigate the association between vitamin B12 levels and postural orthostatic tachycardia syndrome (POTS) during adolescence when accelerated myelin synthesis increases the vitamin B12 need.
One hundred twenty-five patients (mean age 11.1 ± 2.3 years; 60% female) reporting short-term loss of consciousness and diagnosed with vasovagal syncope based on anamnesis with a normal distribution and 50 control subjects (mean age 10.94 ± 2.5 years, 62% female) were included in this study. Serum vitamin B12, folic acid, and ferritin levels were measured prospectively in addition to other tests. We defined vitamin B12 deficiency as a serum level <300 pg/mL.(1-4) RESULTS: Vitamin B12 levels were significantly lower in the patient group compared with the control group (47.2% vs 18%, P < .001). In the patient group, children with the POTS pattern had significantly lower vitamin B12 levels compared with children without the POTS response (P = .03).
Vitamin B12 deficiency in patients with POTS may lead to sympathetic nervous system baroreceptor dysfunction.
维生素 B12 参与去甲肾上腺素向肾上腺素的转化。它是儿茶酚胺降解所涉及的辅助因子，并在髓鞘合成中发挥作用。本研究旨在探讨青少年时期维生素 B12 水平与体位性心动过速综合征（POTS）之间的关系，因为在此期间髓鞘合成加速会增加维生素 B12 的需求。
本研究纳入了 125 名（平均年龄 11.1 ± 2.3 岁；60%为女性）有短暂性意识丧失病史并根据病史诊断为血管迷走性晕厥的患者（正态分布），以及 50 名（平均年龄 10.94 ± 2.5 岁，62%为女性）对照者。除其他检查外，前瞻性测量了血清维生素 B12、叶酸和铁蛋白水平。我们将血清维生素 B12 水平<300 pg/mL 定义为维生素 B12 缺乏症。
与对照组相比，患者组的维生素 B12 水平显著降低（47.2%比 18%，P <.001）。在患者组中，有 POTS 模式的儿童的维生素 B12 水平明显低于没有 POTS 反应的儿童（P =.03）。
POTS 患者的维生素 B12 缺乏可能导致交感神经系统压力感受器功能障碍。
