Chen Guangdong, Bian Haiman, Jiang Deguo, Cui Mingwei, Ji Shengzhang, Liu Mei, Lang Xu, Zhuo Chuanjun
Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 325000, P.R. China.
Department of Radiology, Tianjin 4th Centre Hospital, Tianjin 300143, P.R. China.
Biomed Rep. 2016 Dec;5(6):675-680. doi: 10.3892/br.2016.796. Epub 2016 Oct 31.
Many previous studies have reported that regional cerebral blood flow (rCBF) aberrations may be one of the pathological characteristics of depression and rCBF has demonstrated a certain degree of asymmetry. However, studies investigating the cerebral blood perfusion asymmetry changes of drug-naïve patients experiencing their first episode of major depression using pseudo-continuous arterial spin labeling (pCASL) are rare. Ten drug-naïve patients experiencing their first major depression episode and 15 healthy volunteers were enrolled in the current study. A novel pCASL method was applied to whole brain MRI scans of all of the samples. The Statistics Parameter Mapping and Relative Expression Software Tool software packages were used for the pre-processing and statistical analysis of the two sets of images, and the differences in the cerebral blood perfusion at the whole brain level were compared between the two groups. Compared with the healthy control group, the cerebral perfusion of the depression patients showed an asymmetric pattern. Decreased cerebral blood perfusion regions were primarily located in the left hemisphere, specifically in the left temporal lobe, frontal lobe and cingulate cortex [P<0.05 and cluster size ≥30 with false discovery rate (FDR) correction]. Simultaneously, increased perfusion regions were predominantly located in the right hemisphere, specifically in the right cerebellum, thalamus, frontal lobe and anterior cingulate cortex (P<0.05 and cluster size ≥30, with FDR correction). Thus, pCASL may characterize the alterations in cerebral blood perfusion of patients with depression.
许多先前的研究报告称，局部脑血流量（rCBF）异常可能是抑郁症的病理特征之一，且rCBF已表现出一定程度的不对称性。然而，使用伪连续动脉自旋标记（pCASL）研究首次发作的未用药的重度抑郁症患者脑血流灌注不对称变化的研究很少。本研究纳入了10名首次发作重度抑郁症的未用药患者和15名健康志愿者。一种新型的pCASL方法应用于所有样本的全脑MRI扫描。使用统计参数映射和相对表达软件工具软件包对两组图像进行预处理和统计分析，并比较两组在全脑水平上的脑血流灌注差异。与健康对照组相比，抑郁症患者的脑灌注呈现出不对称模式。脑血流量减少的区域主要位于左半球，特别是左颞叶、额叶和扣带回皮质[P<0.05且聚类大小≥30，经错误发现率（FDR）校正]。同时，灌注增加的区域主要位于右半球，特别是右小脑、丘脑、额叶和前扣带回皮质（P<0.05且聚类大小≥30，经FDR校正）。因此，pCASL可能能够表征抑郁症患者脑血流灌注的变化。
