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通过磷酸三酯法合成用于光 CIDNP 实验的核苷酸-氨基酸缀合物。

Synthesis of nucleotide-amino acid conjugates designed for photo-CIDNP experiments by a phosphotriester approach.

机构信息

Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia ; Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia.

Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia ; International Tomography Center, SB RAS, Institutskaya 3a, Novosibirsk 630090, Russia.

出版信息

Beilstein J Org Chem. 2013 Dec 18;9:2898-909. doi: 10.3762/bjoc.9.326. eCollection 2013.

DOI:10.3762/bjoc.9.326
PMID:24367455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3869286/
Abstract

Conjugates of 2'-deoxyguanosine, L-tryptophan and benzophenone designed to study pathways of fast radical reactions by the photo Chemically Induced Dynamic Nuclear Polarization (photo-CIDNP) method were obtained by the phosphotriester block liquid phase synthesis. The phosphotriester approach to the oligonucleotide synthesis was shown to be a versatile and economic strategy for preparing the required amount of high quality samples of nucleotide-amino acid conjugates.

摘要

通过磷酸三酯块液相合成，获得了设计用于通过光化学诱导动态核极化（photo-CIDNP）方法研究快速自由基反应途径的 2'-脱氧鸟苷、L-色氨酸和苯甲酮的缀合物。磷酸三酯方法在寡核苷酸合成中是一种通用且经济的策略，可用于制备所需量的核苷酸-氨基酸缀合物的高质量样品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/7d0fd23a7975/Beilstein_J_Org_Chem-09-2898-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/95fe48d1b50f/Beilstein_J_Org_Chem-09-2898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/4cc4acb48cb6/Beilstein_J_Org_Chem-09-2898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/2358fd017097/Beilstein_J_Org_Chem-09-2898-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/0d658604fc56/Beilstein_J_Org_Chem-09-2898-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/7d0fd23a7975/Beilstein_J_Org_Chem-09-2898-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/95fe48d1b50f/Beilstein_J_Org_Chem-09-2898-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/4cc4acb48cb6/Beilstein_J_Org_Chem-09-2898-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/2358fd017097/Beilstein_J_Org_Chem-09-2898-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/0d658604fc56/Beilstein_J_Org_Chem-09-2898-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3253/3869286/7d0fd23a7975/Beilstein_J_Org_Chem-09-2898-g006.jpg

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