Yam Felix K, Adams Aimee G, Divine Holly, Steinke Douglas, Jones Mikael D
UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California , San Diego. La Jolla, CA ( United States ).
College of Pharmacy, University of Kentucky . Lexington, KY ( United States ).
Pharm Pract (Granada). 2013 Oct;11(4):203-10. doi: 10.4321/s1886-36552013000400005. Epub 2013 Dec 20.
Evidence suggests that patients with type 2 diabetes (T2DM) suffer from a high rate of "clinical inertia" or "recognition of the problem but failure to act."
THE AIM OF THIS STUDY IS TO QUANTIFY THE RATE OF CLINICAL INERTIA BETWEEN TWO MODELS OF CARE: Pharmacist-Managed Diabetes Clinic (PMDC) vs. Usual Medical Care (UMC).
Patients in a university based medical clinic with type 2 diabetes (T2DM) were analyzed in this retrospective cohort study. Patients were exposed to either PMDC or UMC. The difference in days to intervention in response to suboptimal laboratory values and time to achieve goal hemoglobin A1c (A1c), systolic blood pressure (SBP) and low-density lipoprotein (LDL) was compared in the two models of care.
A total of 113 patients were included in the analysis of this study, 54 patients were in the PMDC and 59 patients were in the UMC group. Median time (days) to intervention for A1c values >7% was 8 days and 9 days in the PMDC and UMC groups, respectively (p>0.05). In patients with baseline A1c values >8%, median time to achieving A1c<7% was 259 days vs. 403 days in the PMDC and UMC groups, respectively (p<0.05). Median time to goal SBP was 124 days in the PMDC group and 532 days in the UMC group (p<0.05). Median time to goal LDL was 412 days in the PMDC group vs. 506 days in the UMC group (p<0.05).
Rates of clinical inertia, defined as time to intervention of suboptimal clinical values, did not differ significantly between patients enrolled in a PMDC compared to patients with UMC with respect to A1c, SBP and LDL. Participation in PMDC, however, was associated with achieving goal A1c, SBP, and LDL levels sooner compared to UMC.
有证据表明,2型糖尿病(T2DM)患者存在较高的“临床惰性”,即“认识到问题但未采取行动”。
本研究的目的是量化两种护理模式之间的临床惰性发生率:药剂师管理的糖尿病诊所(PMDC)与常规医疗护理(UMC)。
在这项回顾性队列研究中,对一家大学附属医院中患有2型糖尿病(T2DM)的患者进行了分析。患者接受了PMDC或UMC治疗。比较了两种护理模式下,针对次优实验室值进行干预的天数差异,以及达到目标糖化血红蛋白(A1c)、收缩压(SBP)和低密度脂蛋白(LDL)的时间差异。
本研究分析共纳入113例患者,其中54例患者在PMDC组,59例患者在UMC组。PMDC组和UMC组中,糖化血红蛋白值>7%时的干预中位时间(天)分别为8天和9天(p>0.05)。基线糖化血红蛋白值>8%的患者中,PMDC组和UMC组达到糖化血红蛋白<7%的中位时间分别为259天和403天(p<0.05)。PMDC组达到目标收缩压的中位时间为124天,UMC组为532天(p<0.05)。PMDC组达到目标低密度脂蛋白的中位时间为412天,UMC组为506天(p<0.05)。
就糖化血红蛋白、收缩压和低密度脂蛋白而言,在次优临床值干预时间方面,PMDC组患者与UMC组患者之间的临床惰性发生率没有显著差异。然而,与UMC相比,参与PMDC与更快达到糖化血红蛋白、收缩压和低密度脂蛋白目标水平相关。