Acosta L, Castro M, Fernandez M, Oliveres E, Gomez-Demmel E, Tartara L
Servicio de Oftalmología, Hospital Privado, Córdoba, Argentina.
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Arch Soc Esp Oftalmol. 2014 Feb;89(2):48-52. doi: 10.1016/j.oftal.2013.09.002. Epub 2013 Dec 22.
To assess the efficacy of platelet rich plasma (PRP) in the treatment of extensive corneal ulcers in albino rabbits.
New Zealand rabbits, divided in 3 groups, were used for the study. Corneal ulcers of 10mm diameter were made. Rabbits blood was extracted for the preparation of the PRP of the corresponding group. The blood was processed by differential centrifugation. The first group, named control, was treated with sterile saline every 8h. The second group, named gel, was treated with deproteinized extract gel beef fat every 8h, and the third group, named PRP received one PRP drop on the first and third day of monitoring. The rabbits were monitored, by taking photographs, each day for the 7 days that the study lasted.
A better outcome was observed in the group with deproteinized extract gel beef fat (GE group), and the PRP group (PL group), in comparison with the control group (CO group) (P<.05).
The PRP showed to be just as effective as the commercial product (Solcoseryl®), for the regeneration of the extensive and deep corneal ulcers. Besides, it stands out as a no surgical procedure is required, and there is easy access, low cost and reduced doses.
评估富血小板血浆（PRP）对白化兔大面积角膜溃疡的治疗效果。
将新西兰兔分为3组用于该研究。制作直径为10mm的角膜溃疡。抽取兔血制备相应组的PRP。血液通过差速离心法处理。第一组为对照组，每8小时用无菌盐水治疗。第二组为凝胶组，每8小时用脱蛋白提取物凝胶牛脂治疗，第三组为PRP组，在监测的第一天和第三天各滴入一滴PRP。在研究持续的7天里，每天对兔子进行拍照监测。
与对照组（CO组）相比，脱蛋白提取物凝胶牛脂组（GE组）和PRP组（PL组）观察到更好的结果（P<0.05）。
PRP在大面积深层角膜溃疡的再生方面显示出与商业产品（素高捷疗®）同样的效果。此外，它的突出之处在于无需手术，获取容易，成本低且剂量减少。
