Wu Tzu En, Chen Chiung Ju, Hu Chao-Chien, Cheng Cheng-Kuo
Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Taiwan J Ophthalmol. 2015 Jul-Sep;5(3):132-135. doi: 10.1016/j.tjo.2014.09.001. Epub 2014 Nov 20.
As platelets are rich in growth factors for tissue regeneration, autologous platelet-rich plasma (PRP) has been used to treat some refractory corneal defects. Although PRP is effective, the cost of its preparation is very high. This article presents three cases of refractory corneal ulcer under the prescription of autologous PRP. The autologous PRP used in these cases was easily prepared in the blood bank laboratory. In this paper, we collected three patients with refractory corneal ulcer who were unresponsive to conventional treatment. The patients presented with neurotrophic ulcer, exposure corneal ulcer, and limbal deciency with corneal ulcer after hepatitic keratitis. Although we easily prepared autologous PRP eye drops using simple laboratory centrifugation, this preparation still had a clinical effect on corneal defect. The mean intervention time was 24 ± 6.9 days. The case with exposure corneal ulcer had significant wound healing and the other two cases felt subjective symptom relief. There were some clinical improvements of refractory corneal ulcers in our three cases. We present the clinical results of three cases and report an easy procedure for the preparation of autologous PRP. Autologous PRP prepared simply in the laboratory, it may be an alternative option for treating refractory corneal ulcer.
由于血小板富含促进组织再生的生长因子，自体富血小板血浆（PRP）已被用于治疗一些难治性角膜缺损。尽管PRP有效，但其制备成本非常高。本文介绍了3例在自体PRP治疗方案下的难治性角膜溃疡病例。这些病例中使用的自体PRP在血库实验室中很容易制备。在本文中，我们收集了3例对传统治疗无反应的难治性角膜溃疡患者。这些患者分别患有神经营养性溃疡、暴露性角膜溃疡以及肝炎性角膜炎后伴有角膜溃疡的角膜缘缺损。尽管我们使用简单的实验室离心法就轻松制备了自体PRP滴眼液，但这种制剂对角膜缺损仍有临床效果。平均干预时间为24±6.9天。暴露性角膜溃疡病例的伤口愈合显著，另外两例患者主观症状缓解。我们的3例难治性角膜溃疡患者有一些临床改善。我们展示了3例的临床结果，并报告了一种简单的自体PRP制备方法。在实验室中简单制备的自体PRP可能是治疗难治性角膜溃疡的一种替代选择。
