醋酸氯地孕酮对慢性阻塞性肺疾病患者睡眠时动脉血氧饱和度下降的影响。

Effect of chlormadinone acetate on sleep arterial oxygen desaturation in patients with chronic obstructive pulmonary disease.

作者信息

Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Watanabe S, Honda Y

出版信息

Chest. 1987 May;91(5):688-92. doi: 10.1378/chest.91.5.688.

DOI:10.1378/chest.91.5.688

Abstract

Twelve patients with chronic obstructive pulmonary disease (COPD) were studied in order to evaluate the effect of chlormadinone acetate (CMA), a potent synthetic progesterone, on the degree of hypoxemia during sleep. In patients designated as "correctors," in whom an increase in minute ventilation (VI) during wakefulness was brought about mainly by an increase in tidal volume (VT) and PaCO2 was effectively decreased by the administration of CMA, this agent also proved to be effective during sleep, with hypoxemia improved during both NREM and REM sleep. On the other hand, in patients called "noncorrectors" in whom a decrease in PaCO2 was not seen during wakefulness with CMA, there was also no effect during sleep. These results indicate that CMA is effective in certain selected patients with COPD.

摘要

为了评估强效合成孕激素醋酸氯地孕酮（CMA）对睡眠期间低氧血症程度的影响，对12例慢性阻塞性肺疾病（COPD）患者进行了研究。在被指定为“纠正者”的患者中，清醒时分钟通气量（VI）增加主要是由潮气量（VT）增加引起的，并且通过给予CMA可有效降低动脉血二氧化碳分压（PaCO2），该药物在睡眠期间也被证明是有效的，在非快速眼动（NREM）睡眠和快速眼动（REM）睡眠期间低氧血症均得到改善。另一方面，在被称为“非纠正者”的患者中，清醒时使用CMA未观察到PaCO2降低，睡眠期间也没有效果。这些结果表明，CMA对某些选定的COPD患者有效。